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. 2015 Jan 29;21(5):425–434. doi: 10.1111/cns.12375

Figure 3.

Figure 3

Leptin induces the reversal of conditioning‐induced potentiation in the LA. (A) Diagram of slice preparation with stimulation and recording sites indicated. CE, central nucleus. (B) The behavioral procedure for the electrophysiology experiments shown in C–F. Brain slices were prepared on day 3 for all groups. (C) Fear learning facilitated synaptic transmission in the thalamic‐LA pathway 2 day post‐training. (D) Leptin reversed of conditioning‐induced potentiation in the LA through NMDA receptor. Synaptic strength in slices from NS control, leptin, and MK‐801 + leptin groups after fear extinction training. Leptin facilitated the dampening of conditioning‐induced potentiation in the LA. MK‐801 robustly blocked this effect of leptin. (E) Bar graph showing the maximum amplitude of fEPSPs in slices from mice after behavioral experiments. *P < 0.05 relative to unpaired control; # P < 0.05 relative to paired; & P < 0.05 relative to leptin. (F) Traces of fEPSPs were recorded at increasing stimulus intensities on day 3 in slices from for all five groups. n = 7 for each group.