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. 2015 Jan 29;21(5):425–434. doi: 10.1111/cns.12375

Figure 4.

Figure 4

Leptin facilitates NMDA receptor (NMDAR)‐mediated synaptic transmission in the LA (thalamic input). (A) NMDAR‐mediated fEPSPs were isolated by pharmacological manipulation in the LA. D‐APV (50 μM) blocked the NMDAR‐mediated fEPSPs completely. (B) NMDAR‐mediated synaptic transmission was enhanced by leptin (50 nM). (C–E) Effect of leptin (1, 10 and 50 nM) on NMDAR‐mediated fEPSPs in LA. The superimposed fEPSPs in the top portion showed respective recordings from example experiments taken at the time indicated by the number. (F) The histogram showed the level of NMDAR‐mediated fEPSPs 30 min after the presence of various concentrations of leptin. *P < 0.05 versus control. Each point was the normalized mean ± SEM of slices.