Table 2.

 Model parameters for population balance equation (PBE) modelling approach used in the simulation. Parameters µ′ and α_P were obtained by fitting model results and experimental data for experiments carried out when initial cell number was equal to 3.68 × 10⁴ (Run 1). These parameters have been also used to test the model predictive capability for experiments performed starting with 2.3 × 10⁴ and 1.0 × 10⁴ (i.e. Runs 2–3) as initial cell number

Parameter	Value	Unit	Reference
	0.203 × 10−6	mmol/mm3	Schumpe et al. (41)
Cm	0.006 × 10−6	mmol/mm3	Obradovic et al. (42)
dc	1.14 × 106	ng/mm3	Jakob et al. (40)
N 0	Run 1: 3.68 × 104	Cells	This work
	Run 2: 2.3 × 104
	Run 3: 1.0 × 104
q	40	–	Mantzaris et al. (19)
V	800	mm3	This work
αP	10.8	–	This work (tuned parameter)
ϕa	800	mm2	This work
µ	3.8	ng	This work
µ0	2	ng	This work
µc	1.0 × 10−3	1/h	Munteanu et al. (43)
µ′	97.4	ng/(mm2 h)	This work (tuned parameter)
σ	1.125	ng	This work
σ0	0.4	ng	This work