Table 1.
Phenotypic characteristics of interspecific cybird cells crossed between the anucleated reticulocytes (or nucleated erythroblasts) and the HGPRT‐deficient myeloma or erythroleukaemia cell lines
| Normal parental cytoplast | Malignant parental cell line | Cybrid cell | Phenotype characters |
|---|---|---|---|
| Mouse reticulocyte (RM) | Human HL‐60‐AR pro‐myelocytic leukaemia mutant (HL) | HL‐RM cybrid | Malignancy reversion a expression of human haemoglobins |
| Neo transferred rabbit reticulocyte (RRneo) | Human K562 erythroleukaemia cell (K) | K‐RRneo cybrid | Malignancy reversion a expression of human haemoglobins, repression of vimentin gene |
| Mouse B‐lymphocyte (non‐erythroid control) | Mouse NS‐1 | Lymphocyte hybridomas | Plasmacytoma (k) tumour |
a
Refers to the decrease in growth rate, mitotic index and DNA synthesis, loss of colony‐forming ability in soft agar medium and non‐tumorigenecity in nude mice.