Table 1.
Repopulation mechanisms and their effect on different cell types
Repopulation mechanism | Effect/definition | Type of cells affected |
---|---|---|
Cell recruitment | Recycling the quiescent cells into the cell cycle | Quiescent cells |
Accelerated repopulation | Shortening of cell cycle time | Proliferating stem cells |
Loss of asymmetrical division | Symmetrical division of stem cells in mitosis (i.e. two daughter stem cells) | Proliferating stem cells |
Abortive division | Limited number of proliferations after which the cell becomes sterile | Proliferating differentiated cells (finitely proliferating cells or doomed cells) |