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Dose-response and kill kinetics of TBI-166 in the chronic mouse infection model. Eight weeks of treatment with vehicle (CMC), 10 mg/kg RIF, 20 mg/kg CFZ, or 10 to 80 mg/kg TBI-166; treatment was initiated on day 28 postinfection. Dosages are in milligrams per kilogram of body weight. All mice were sacrificed prior to treatment or after 2, 4, and 8 weeks of treatment.
