TABLE 1.

MICs of TBI-166 against different mycobacterial species

Mycobacterial species and/or straina	No. of strains	MIC data (μg/ml) by drugb
		TBI-166		CFZ
		Range	Median	Range	Median
M. tuberculosis H37Rv	1	NA	0.063	NA	0.25
M. tuberculosis fully susceptible clinical isolates	16	<0.005–0.15	0.038	0.026–0.633	0.227
M. tuberculosis resistant to RIF	1	NA	0.099	NA	0.224
M. tuberculosis resistant to INH and RIF	2	0.017–0.025	0.021	0.15–0.264	0.207
M. tuberculosis resistant to INH and STR	1	0.018	0.018	0.386	0.386
M. tuberculosis resistant to RIF and EMB	1	NA	0.2	NA	0.3
M. tuberculosis resistant to INH, RIF, and LVX	1	NA	0.026	NA	0.064
M. tuberculosis resistant to INH, RIF, and STR	1	NA	0.1	NA	0.3
M. tuberculosis resistant to RIF, STR, and EMB	1	NA	0.1	NA	0.3
M. tuberculosis resistant to INH, RIF, and EMB	3	0.013–0.098	0.025	0.075–0.3	0.143
M. tuberculosis resistant to RIF, STR, LVX, and EMB	2	0.1–0.164	0.132	0.15–0.544	0.347
M. tuberculosis resistant to INH, RIF, LVX, and EMB	4	0.019–0.05	0.0385	0.095–0.486	0.2425
M. tuberculosis resistant to INH, RIF, STR, and EMB	5	0.01–0.2	0.1	0.15–0.3	0.219
M. tuberculosis resistant to INH, RIF, STR, LVX, and EMB	6	0.039–0.2	0.1125	0.118–0.844	0.4095
M. kansasii	1	NA	0.183	NA	1.776
M. scrofulaceum	1	NA	1.49	NA	0.292
M. fortuitum	1	NA	0.688	NA	0.276

^aRIF, rifampin; INH, isoniazid; STR, streptomycin; EMB, ethambutol; LVX, levofloxacin.

^bNA, not applicable.