TABLE 3.

Distribution and accumulation of 20 mg/kg TBI-166 and CFZ in uninfected mice after 2, 4, and 8 weeks of exposure

Drug	Infection site	Concn (μg/g) by exposure time
		2 wk	4 wk	8 wk
TBI-166	Lung	27.12 ± 6.15	28.91 ± 12.33	44.28 ± 12.62
CFZ		7.92 ± 7.10	31.87 ± 2.82	32.88 ± 10.28
TBI-166	Liver	32.29 ± 9.68	53.60 ± 42.66	108.17 ± 46.93
CFZ		2.01 ± 0.92	4.94 ± 2.02	12.75 ± 0.87
TBI-166	Spleen	27.98 ± 11.17	16.83 ± 15.39	36.54 ± 19.52
CFZ		13.18 ± 3.35	33.30 ± 0.97	36.47 ± 4.71
TBI-166	Fat		576.45 ± 307.52	1,336.34 ± 503.18
CFZ			180.07 ± 88.66	253.27 ± 28.50
TBI-166	Skin		103.51 ± 71.50	169.23 ± 15.91
CFZ			47.78 ± 19.67	41.57 ± 13.88