TABLE 2.
MICs and categorization according to CLSI breakpoints for antimicrobials on MBL-producing Enterobacteriaceae, MBL-producing P. aeruginosa, and S. maltophilia
| Enterobacteriaceae sp. | β-Lactamases | MICs (mg/liter) by treatmenta |
||||||
|---|---|---|---|---|---|---|---|---|
| ATM | CZA | C/T | AMC | ATM+CZA | ATM+C/T | ATM+AMC | ||
| E. coli | NDM-1 + OXA-1 + OXA-10 + CMY-16 + TEM-1 | 32 | >256 | >256 | 16 | 0.125 | 24 | 8 |
| E. coli | NDM-1 + CTX-M-15 + TEM-1 | >256 | >256 | >256 | 12 | 1 | >256 | 2 |
| E. coli | NDM-1 + OXA-1 + OXA-2 + CTX-M-15 + TEM-1 | >256 | >256 | >256 | 24 | 2 | >256 | 8 |
| E. coli | NDM-1 + CTX-M-15 + TEM-1 | >256 | >256 | >256 | 32 | 6 | >256 | 8 |
| E. coli | NDM-4 + CTX-M-15 + OXA-1 | >256 | >256 | >256 | 96 | 6 | >256 | 4 |
| E. coli | NDM-4 + CTX-M-15 + CMY-6 | >256 | >256 | >256 | >256 | 6 | >256 | 24 |
| E. coli | NDM-5 + TEM-1 + CTX-M-15 | >256 | >256 | >256 | 96 | 8 | >256 | 64 |
| E. coli | NDM-6 + CTX-M-15 + OXA-1 | >256 | >256 | >256 | 16 | 1 | >256 | 2 |
| E. coli | NDM-7 + ESBL | >256 | >256 | >256 | 96 | 4 | >256 | 32 |
| K. pneumoniae | NDM-1 + CTX-M-15 + SHV-11 + OXA-1 | >256 | >256 | >256 | 12 | 0.125 | 24 | 0.38 |
| K. pneumoniae | NDM-1 + CTX-M-15 + CMY-4 + OXA-1 | >256 | >256 | >256 | 32 | 0.75 | >256 | 16 |
| K. pneumoniae | NDM-1 + CTX-M-15 + OXA-1 + OXA-9 + TEM-1 + SHV-28 + SHV-11 | >256 | >256 | >256 | 32 | 0.25 | >256 | 3 |
| K. pneumoniae | NDM-1 + OXA-1 + SHV-11 | >256 | >256 | >256 | 12 | 0.047 | 0.094 | 0.094 |
| K. pneumoniae | NDM-1 + OXA-1 + CTX-M-15 + TEM-1 + SHV-28 + OXA-9 + CMY-6 | >256 | >256 | >256 | 16 | 0.047 | 3 | 0.25 |
| K. pneumoniae | NDM-1 + TEM-1 + CTX-M-15 + SHV-12 + OXA-9 | >256 | >256 | >256 | 12 | 0.125 | 96 | 1 |
| K. pneumoniae | NDM-1 + TEM-1 + CTX-M-15 + SHV-12 + OXA-9 | >256 | >256 | >256 | 12 | 0.125 | 96 | 0.5 |
| K. pneumoniae | NDM-1 + TEM-1 + CTX-M-15 + SHV-11 + OXA-1 | >256 | >256 | >256 | 12 | 0.064 | 8 | 0.38 |
| Salmonella enterica | NDM-1 + CTX-M-15 + TEM-1 + OXA-1 + OXA-9 + OXA-10 | >256 | >256 | >256 | 16 | 0.125 | 16 | 0.5 |
| E. coli | VIM-1 + CTX-M-3 | >256 | >256 | >256 | 16 | 0.125 | 24 | 0.5 |
| E. coli | VIM-4 + ESBL | 16 | >256 | >256 | 24 | 1.5 | 24 | 16 |
| K. pneumoniae | VIM-1 + SHV-5 | >256 | >256 | >256 | >256 | 0.25 | 192 | 1.5 |
| K. pneumoniae | VIM-1 + SHV-12 | >256 | >256 | >256 | 16 | 0.125 | 4 | 0.25 |
| K. pneumoniae | VIM-1 + ESBL | >256 | >256 | >256 | >256 | 12 | 16 | 12 |
| K. pneumoniae | VIM-1 + SHV-5 | 16 | >256 | >256 | >256 | 6 | 12 | 32 |
| K. pneumoniae | VIM-1 + TEM-1 + SHV-5 | 96 | >256 | >256 | >256 | 96 | 64 | 48 |
| K. pneumoniae | VIM-1 + SHV-5 | >256 | >256 | >256 | 24 | 0.25 | 8 | 0.75 |
| K. pneumoniae | VIM-1 + SHV-5 | >256 | >256 | >256 | 12 | 0.125 | 2 | 0.38 |
| K. pneumoniae | VIM-19 + CTX-M-3 + TEM-1 + SHV-1 | 6 | 32 | >256 | 16 | 0.047 | 2 | 1.5 |
| Enterobacter cloacae | VIM-1 + SHV-70 | 256 | 128 | >256 | 48 | 0.094 | 0.25 | 0.19 |
| E. cloacae | VIM-4 + CTX-M-15 + TEM-1 + SHV-31 | 64 | >256 | >256 | 64 | 1 | 64 | 32 |
| Citrobacter freundii | VIM-2 + TEM-1 + ESBL | 16 | 16 | >256 | 32 | 0.25 | 2 | 24 |
| C. freundii | VIM-2 + TEM-1 + OXA-9 + OXA-10 | 32 | 24 | >256 | 32 | 1.5 | 16 | 24 |
| E. coli | IMP-8 + SHV-12 | 128 | >256 | >256 | 24 | 0.19 | 2 | 0.38 |
| K. pneumoniae | IMP-8 + SHV-12 | >256 | 48 | >256 | 12 | 0.094 | 32 | 0.25 |
| E. cloacae | IMP-8 + SHV-12 | 12 | >256 | >256 | 24 | 0.032 | 0.064 | 0.094 |
| E. cloacae | GIM-1 + ESBL | 12 | >256 | 48 | 24 | 0.5 | 8 | 16 |
| Enterobacter hormaechei | TMB-1 + overexpressed Caseb | 64 | 64 | 32 | 32 | 0.5 | 12 | 12 |
| C. freundii | TMB-1 + overexpressed Case | 64 | 96 | 32 | 12 | 0.125 | 12 | 12 |
| K. pneumoniae | NDM-1 + OXA-181 + SHV-11 + TEM-1 + CTX-M-15 + OXA-1 | 64 | >256 | >256 | 48 | 0.094 | 8 | 2 |
| K. pneumoniae | NDM-1 + OXA-181 + SHV-27 + CTX-M-15 + TEM-1 + OXA-1 | 128 | >256 | >256 | 96 | 0.25 | 16 | 3 |
| K. pneumoniae | NDM-1 + OXA-181 + SHV-11 + CTX-M-15 + OXA-1 | 256 | >256 | >256 | >256 | 0.19 | 32 | 3 |
| K. pneumoniae | NDM-1 + OXA-181 + SHV-11 + TEM-1 + CTX-M-15 + OXA-9 | >256 | >256 | >256 | >256 | 0.19 | >256 | 12 |
| K. pneumoniae | NDM-1 + OXA-181 + SHV-2 + CTX-M-15 + OXA-1 | >256 | >256 | >256 | 32 | 0.125 | 32 | 1.5 |
| C. freundii | NDM-1 + OXA-181 + OXA-1 + OXA-9 + OXA-10 + CTX-M-15 + TEM-1 | >256 | >256 | >256 | 64 | 0.75 | >256 | 12 |
| E. coli | NDM-1 + OXA-48 + ESBL | 32 | >256 | >256 | 48 | 0.094 | 12 | 8 |
| E. coli | NDM-1 + OXA-48 + ESBL | >256 | >256 | >256 | >256 | 0.75 | >256 | 4 |
| E. coli | NDM-1 + OXA-48 + ESBL | >256 | >256 | >256 | >256 | 1 | >256 | 4 |
| K. pneumoniae | NDM-1 + OXA-232 + ESBL | 64 | >256 | >256 | >256 | 0.094 | 24 | 3 |
| E. coli | NDM-1 + OXA-232 + ESBL | >256 | >256 | >256 | >256 | 1 | >256 | 8 |
| E. coli | NDM-5 + OXA-232 + ESBL | >256 | >256 | >256 | 96 | 1 | >256 | 64 |
| S. maltophilia | >256 | >256 | >256 | 32 | 2 | 128 | 2 | |
| S. maltophilia | >256 | >256 | 6 | 96 | 1.5 | 6 | 2 | |
| S. maltophilia | >256 | >256 | >256 | >256 | 4 | >256 | 4 | |
| S. maltophilia | >256 | 16 | 72 | 16 | 1 | 8 | 2 | |
| S. maltophilia | >256 | >256 | >256 | >256 | 0.75 | 24 | 0.75 | |
| P. aeruginosa | VIM-2 + overexpressed cephalosporinase | 16 | 24 | >256 | >256 | 8 | 12 | 16 |
| P. aeruginosa | IMP-2 + overexpressed cephalosporinase | 12 | >256 | >256 | >256 | 6 | 12 | 24 |
| P. aeruginosa | IMP-1 + overexpressed cephalosporinase | 128 | >256 | >256 | >256 | 96 | 48 | 64 |
a
Black, gray, and white colored MICs correspond to resistant, intermediate, and susceptible categorization, respectively, according to CLSI breakpoints, as updated in 2018. Pseudomonas sp. breakpoints were used for Stenotrophomonas maltophilia. ATM, aztreonam; CZA, ceftazidime-avibactam; C/T, ceftolozane-tazobactam; AMC, amoxicillin-clavulanate.
b
Case, chromosome-encoded cephalosporinase.