FIG 1.

Aminomethyl spectinomycin effective for treatment of acute otitis media. Mice infected with S. pneumoniae (A) or H. influenzae (B) and subsequently treated with a single dose of vehicle, ampicillin, or 1950. Bacterial burden in the ears was measured by CFU enumeration at 24 h postchallenge. Groups were compared by Mann-Whitney U testing. *, indicates P < 0.05 compared with vehicle control group for (A) and (B). Each data point represents an individual ear. Dotted line indicates the limit of detection. (C) Structure of aminomethyl spectinomycin analog 1950. (D) The zone of inhibition was compared for each species between spectinomycin and 1950 by Mann-Whitney U testing, with the asterisk (*) indicating P < 0.05.