FIG 4.

The 1950 treatment reduces the extent of alveolar involvement during pneumococcal pneumonia. Representative lung sections subjected hematoxylin and eosin staining of vehicle (A, B), ampicillin (C, D), and 1950 (E, F) at 24 h postchallenge. Scale bar for ×4 magnification in (A, C, and E) is 1 mm and indicated in (A). Scale bar for ×10 magnification in (B, D, and F) is 200 μm and indicated in (A). Pathologist scores for (G) indicated 1950 significantly reduced the extent of alveolar involvement in lung inflammation in a manner indistinguishable from ampicillin treatment. No differences were observed at this time point in terms of severity of perivascular inflammation and edema (H). Groups were compared by Mann-Whitney U testing. *, indicates P < 0.05 compared with vehicle control group. Each data point represents scores from one animal.