FIG 5.

Efficacy of 1950 in mixed bacterial infections. Bacterial burden from S. pneumoniae/H. influenzae coinfected lungs (A, B) and S. pneumoniae/M. catarrhalis coinfected infected lungs (C, D) following treatment with vehicle, ampicillin, or 1950. Bacterial burden in the lungs was measured by CFU enumeration. Groups were compared by Mann-Whitney U testing. *, indicates P < 0.05 compared with vehicle control group. Each data point represents 1 animal. Dotted line indicates the limit of detection.