TABLE 5.
PKPD analysis of nephrotoxicity
| Parametera | All data | Normal kidney function | Kidney injury | Kidney failure |
|---|---|---|---|---|
| Study size (n) | 713 | 618 | 41 | 54 |
| Aminoglycosides [n (%)] | 405 (56.8) | 336 (54.4) | 30 (73.2) | 39 (72.2) |
| Diuretics [n (%)] | 219 (30.7) | 172 (27.8) | 18 (43.9) | 29 (53.7) |
| NSAIDs [n (%)] | 166 (23.3) | 149 (24.1) | 8 (19.5) | 9 (16.7) |
| Cyclosporine [n (%)] | 112 (15.7) | 78 (12.6) | 11 (26.8) | 23 (42.6) |
| Colistin [n (%)] | 6 (0.842) | 5 (0.809) | 1 (2.44) | 0 (0) |
| No dose change (n) | 381 | 346 | 16 | 19 |
| One dose change (n) | 200 | 170 | 12 | 18 |
| Fraction increased dose at first dose | 0.732 | 0.75 | 0.72 | 0.6 |
| Two dose changes (n) | 102 | 80 | 11 | 11 |
| Fraction increased dose at second dose | 0.682 | 0.676 | 0.672 | 0.706 |
| Three dose changes (n) | 21 | 17 | 1 | 3 |
| Fraction increased dose at third dose | 0.8 | 0.773 | 1 | 0.833 |
| Four dose changes (n) | 8 | 5 | 0 | 3 |
| Fraction increased dose at fourth dose | 0.667 | 0.6 | 1 | |
| Five dose changes (n) | 1 | 0 | 1 | 0 |
| Fraction increased dose at fifth dose | 1 | 1 |
a
Fraction increase dose: the upward number of dose changes over the total number of dose changes.