TABLE 7.

Summary of PKPD analysis of nephrotoxicity using AUC_CUM

Parameter	AUCCUM and kidney injury or failure				AUCCUM and kidney failure
	Estimate	SE	z value	P value	Estimate	SE	z value	P value
Intercept	−11.5	1.42	−8.12	4.68E−16b	−13.4	1.92	−6.96	3.29E−12b
Log(AUCCUM)	1.17	0.178	6.55	5.71E−11b	1.32	0.237	5.57	0.000000026b
Aminoglycosides	0.276	0.276	1	0.317	0.0584	0.358	0.163	0.87
Diuretic	0.179	0.258	0.696	0.486	0.216	0.328	0.657	0.511
NSAIDs	0.0274	0.327	0.0839	0.933	0.104	0.435	0.239	0.811
Cyclosporine	0.549	0.291	1.88	0.0596	0.739	0.358	2.06	0.0391a
Colistin	1.12	1.16	0.962	0.336	−13	923	−0.0141	0.989
Creatinine	0.00591	0.00321	1.84	0.0655	0.00643	0.00361	1.78	0.0751
Age	−0.00369	0.00256	−1.44	0.15	−0.00556	0.00332	−1.68	0.0938
Creatinine/age ratio	−0.000000257	0.0000283	−0.00911	0.993	0.00000702	0.0000303	0.232	0.817

^aP < 0.05.

^bP < 0.01.