TABLE 3.
Multivariate analysis of independent predictors of acute kidney injury in the combined populationa
| Covariate | Odds ratio | 95% CI |
|---|---|---|
| Vancomycin plus piperacillin-tazobactam | 2.161 | 1.620–2.883 |
| Baseline CrCl ≤ 60 ml/min | 2.220 | 1.791–2.751 |
| Vasopressor use | 1.877 | 1.512–2.329 |
| Initial vancomycin trough > 20 μg | 1.680 | 1.281–2.205 |
| Charlson comorbidity index | 1.051 | 1.012–1.091 |
a
Variables included in model: use of piperacillin-tazobactam, cefepime, or meropenem; baseline creatinine clearance below 60 ml/min; use of one or more vasopressor agent; admission to SICU; Charlson comorbidity index; initial vancomycin trough value of >20. Backwards logistic regression was used for multivariate analysis (Hosmer and Lemeshow test value = 0.569).