TABLE 1.
Antimicrobial susceptibilities of MBL-expressing K. pneumoniae isolates
| K. pneumoniae strain | β-Lactamase(s) produced | MIC (μg/ml)a |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZID | WCK 5153 | FEP |
ATM |
IPM | MEM | TGC | ||||||
| Alone | + ZID (4 μg/ml) | + WCK 5153 (4 μg/ml) | Alone | + ZID (4 μg/ml) | + WCK 5153 (4 μg/ml) | |||||||
| 4338 | VIM-1 | >256 | >256 | 32 | 0.5 | 0.5 | 1 | ≤0.5 | ≤0.5 | 4 | 0.5 | 8 |
| 7043 | NDM-1, CTX-M-15 | >256 | 256 | >256 | 32 | 32-64 | >256 | 8 | 4 | 128 | 64 | 4 |
| NCTC 13443 | NDM-1, CMY, SHV, TEM, CTX-M-15 | >256 | >256 | >256 | 4 | 4 | >256 | 2 | 2 | 128 | >128 | 4 |
| AI 1185 | NDM, CMY, TEM, SHV | >256 | >256 | 128 | ≤0.25 | ≤0.25 | >256 | ≤0.25 | ≤0.25 | 128 | 128 | 4 |
| AI 1186 | NDM, CMY, SHV, TEM | >256 | >256 | >128 | ≤0.25 | ≤0.25 | >256 | ≤0.25 | ≤0.25 | 128 | 128 | 0.5 |
| AI 1460 | NDM, CMY SHV, TEM | >256 | >256 | >128 | ≤0.25 | ≤0.25 | >256 | ≤0.25 | ≤0.25 | 128 | 128 | 2 |
a
Microbroth dilution MICs were performed following CLSI M07-A10 guidelines (28). Modal MICs are provided. FEP, cefepime; ATM, aztreonam; ZID, zidebactam; IPM, imipenem; MEM, meropenem; TGC, tigecycline.