TABLE 4.
Amino acid alternations in the quinolone resistance-determining regions of C. indologenes
| Amino acid residue | Levofloxacin resistance |
Ciprofloxacin resistance |
||||||
|---|---|---|---|---|---|---|---|---|
| No. (%) of susceptible isolates (n = 16) | No. (%) of nonsusceptible isolates (n = 68) | OR (95% CI)a | P value | No. (%) of susceptible isolates (n =14) | No. (%) of nonsusceptible isolates (n = 70) | OR (95% CI) | P value | |
| Position 83 of GyrA | ||||||||
| Serine | 13 (81.3) | 11 (16.2) | 22.46 (5.47–92.12) | <0.001 | 13 (92.9) | 11 (15.7) | 69.73 (8.26–588.73) | <0.001 |
| Phenylalanine | 0 | 4 (5.9) | 0.999 | 0 | 4 (5.7) | 0.999 | ||
| Valine | 1 (6.3) | 11 (16.2) | 0.345 (0.04–2.89) | 0.447 | 0 | 12 (17.1) | 0.203 | |
| Tyrosine | 2 (12.5) | 42 (61.8) | 0.09 (0.2–0.42) | <0.001 | 1 (7.1) | 43 (61.4) | 0.05 (0.01–0.39) | <0.001 |
| Position 87 of GyrA | ||||||||
| Aspartate | 15 (93.8) | 29 (42.6) | 20.17 (2.52–161.55) | <0.001 | 13 (92.9) | 31 (44.3) | 16.36 (2.03–131.95) | 0.001 |
| Glycine | 1 (6.3) | 18 (26.5) | 0.19 (0.02–1.5) | 0.104 | 1 (7.1) | 18 (25.7) | 0.22 (0.03–1.82) | 0.174 |
| Histidine | 0 | 1 (1.5) | 0.999 | 0 | 1 (1.4) | 0.999 | ||
| Tyrosine | 0 | 20 (29.4) | 0.01 | 0 | 20 (28.6) | 0.018 | ||
| Position 66 of ParC | ||||||||
| Aspartate | 1 (6.3) | 3 (4.4) | 1.44 (0.14–14.87) | 0.578 | 1 (7.1) | 3 (4.3) | 1.72 (0.17–17.83) | 0.525 |
| Valine | 15 (93.8) | 65 (95.6) | 0.69 (0.07–7.13) | 0.578 | 13 (92.9) | 67 (95.7) | 0.58 (0.06–6.04) | 0.525 |
a
OR, odds ratio; CI, confidence interval.