FIG 1.
A variety of approved medications substantially diminish Candida albicans susceptibility to fluconazole. C. albicans (strain SC5314) susceptibility to fluconazole was tested in the absence (DMSO vehicle alone) or presence of 5 μM of the indicated compounds in RPMI medium according to the CLSI broth microdilution protocol. Growth was quantified as OD600 after 24 h of incubation at 35°C, and data are presented as percent growth relative to the drug-free control. Data represent averages of results from technical duplicates from a single experiment representative of two biological replicates.