FIG 2.
Several antagonistic compounds elevate Candida albicans fluconazole resistance at submicromolar concentrations. Checkerboard assays were performed in RPMI medium with C. albicans (strain SC5314) across a range of fluconazole doses and of (A) aripiprazole, (B) etofenamate, (C) mometasone, (D) penbutolol, (E) pinaverium, (F) prenylamine, and (G) thiethylperazine. After 24 h of incubation at 35°C, the growth in each well was quantified as OD600, normalized to the untreated control well, and data are presented as heat maps. Data represent averages of results from technical duplicates from a single experiment representative of two biological replicates.