FIG 6.
The Tac1p transcription factor is a major mediator of azole-antagonistic drug interactions. The susceptibility of wild-type (SC5314) (A), tac1Δ/Δ (B), and upc2Δ/Δ (C) C. albicans strains to fluconazole was tested in the absence (DMSO vehicle alone) or presence of 5 μM of the indicated compounds in RPMI medium according to the CLSI broth microdilution protocol. Growth was quantified as OD600 after 24 h of incubation at 35°C and expressed as a percentage of growth in the drug-free control, and data are presented as heat maps. Data represent averages of results from technical duplicates from a single experiment representative of two biological replicates.