FIG 7.

Aripiprazole induces transcription of the CDR1 and CDR2 genes in C. albicans. SC5314 was grown in YPD medium buffered with MOPS and adjusted to pH 7 in the presence of the indicated concentrations of drugs or of DMSO vehicle alone before RNA was isolated, and the relative abundance of the CDR1, CDR2, and MDR1 transcripts were determined by qRT-PCR analysis. The relative abundances of these transcripts in each sample were normalized to that of the ACT1 transcript and expressed relative to the level seen with the DMSO control (fold expression). Flu, fluconazole; Ari, aripiprazole; Eto, etofenamate. Mean and standard deviations of results from three separate experiments, each performed with three technical replicates, are shown.