FIG 8.
The Pdr1p transcription factor facilitates azole-antagonistic drug interactions in Candida glabrata. The susceptibility of wild-type (SM1) (A), pdr1Δ (B), and upc2aΔ (C) strains of C. glabrata to fluconazole was tested in the absence (DMSO vehicle alone) or presence of 5 μM of the indicated compounds in RPMI medium according to the CLSI broth microdilution protocol. Growth was quantified as OD600 after 24 h of incubation at 35°C, expressed as a percentage of growth in the drug-free control, and data are presented as heat maps. Data represent averages of results from technical duplicates from a single experiment representative of two biological replicates.