TABLE 1.

Agents from the Prestwick collection that suppress the antifungal activity of fluconazole on Candida albicans or Candida glabrata^a

Screen	Compound	Growth restoration (% of untreated control)
C. albicans, 5 μM fluconazole	Untreated	100
	Fluconazole alone	0
	Fendiline hydrochloride	132
	Methiothepin maleate	122
	Hexetidine	115
	Prenylamine lactate	83
	Mometasone furoate	121
	Etofenamate	102
	Dimethisoquin hydrochloride	58
	Pinaverium bromide	131
	Halofantrine hydrochloride	119
	Penbutolol sulfate	109
	Thiethylperazine dimalate	70
	Toltrazuril	63
	Aripiprazole	122
C. glabrata, 100 μM fluconazole	Untreated	100
	Fluconazole alone	0
	Parthenolide	61
	Estramustine	58

^aThe Prestwick collection, containing a variety of FDA-approved drugs, was screened with each compound at a final concentration of 5 μM to identify those which restore the growth of either C. albicans or C. glabrata in the presence of inhibitory concentrations of fluconazole. Hits were defined as compounds that restored fungal growth to at least 50% of level seen with the untreated control wells.