TABLE 3.

Relative levels of fluconazole resistance induced in Candida albicans by selected antagonistic compounds^a

Compound	Fluconazole resistance
	Strain SC5314	Strain tacΔ/Δ	Strain upc2Δ/Δ
DMSO	1×	1×	1×
Aripiprazole (5 μM)	32×	1×	>4×
Etofenamate (5 μM)	>256×	>128×	1×
Mometasone (5 μM)	16×	1×	>4×
Penbutolol (5 μM)	32×	4×	>2×
Pinaverium (5 μM)	32×	1/2×	>4×
Prenylamine (5 μM)	16×	1×	>2×
Thiethylperazine (5 μM)	8×	1×	>2×

^aFluconazole susceptibility assays were performed using a modified version of the CLSI broth microdilution method for the indicated strains in the presence and absence of the seven indicated compounds at a final concentration of 5 μM. After 24 h of incubation, growth was quantified as OD₆₀₀, and fluconazole MICs determined as the lowest concentration resulting in a 50% decrease in growth. The fluconazole MIC occurring with each drug treatment was then expressed relative to the fluconazole-alone control (DMSO).