TABLE 1.
Contribution of different resistance determinants from A. nosocomialis and A. pittii to carbapenem resistance in A. baumannii
| Straina | Original strain | MIC (μg/ml)b |
|
|---|---|---|---|
| Imipenem | Meropenem | ||
| 2010N07-100 | 1 | 0.5 | |
| 2010N07-100 (pAB-NCGM253-like with blaOXA-72) | 2014E03-147 | >16 | >16 |
| 2010N07-100 (plasmid with IS1006-ΔISAba3-blaOXA-58) | 2010S01-197 | >16 | >16 |
| 2010N07-100 (plasmid with IS15DI-ΔISAba3-blaOXA-58) | 2014N23-120 | >16 | >16 |
| ATCC 17978 (pYMAb2) | ≤0.25 | ≤0.25 | |
| ATCC 17978 (pYMAb2::blaOXA-500)c | 2014S07-126 | ≤0.25 | ≤0.25 |
a
A carbapenem-susceptible A. baumannii clinical isolate (2010N07-100) was the recipient.
b
The MICs were determined using the broth microdilution method.
c
blaOXA-500 belongs to the blaOXA-272-like branch of blaOXA-213-like in A. pittii.