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LOOH enhances formation of 8‐oxoG in CaCo‐2 cells. Cells (3 × 10 6 ) were treated with 1 or 5 µ m LOOH for 24 h. Total DNA was extracted and digested with nucleases to yield the deoxyribonucleosides. 8‐oxoG was resolved by HPLC using electrochemical detection, and quantified by comparison to authentic standards. The results are expressed as the number of 8‐oxoG residues per 2dG residues. Each value is the mean ± SE of five separate experiments. * P < 0.05 versus control.
