Figure 7.

Schematic illustration of the working model for the regulation of F‐actin in mouse fertilized eggs by mTORC2/Akt1/Girdin. Akt1 and Girdin were affected by knockdown of mTORC2. Akt1 positively regulated the development of mouse fertilized eggs by Girdin‐mediated F‐actin remodelling. Girdin protein could be a downstream target of the Akt1 signalling pathway. mTORC2 may regulate Girdin in the development of mouse fertilized eggs. Our current study suggests a critical role of Akt1 as a substrate for mTORC2 and supports an important role for mTORC2 in regulating the development of mouse fertilized eggs through Akt1 and Girdin. Our study indicates that the mTORC2/Akt1/Girdin signalling pathway is crucial for remodelling F‐actin in mouse fertilized eggs