Figure 2.

Clonal morphologies in malignant cell lines. Colony morphologies formed by the CA1 cell line which was derived from an oral carcinoma. (a) A holoclone characterized by its round colony outline and small, closely packed and slightly spindle‐shaped cells. (b) A meroclone with larger, more flattened, central cells that remain in contact with each other unlike cells at the periphery of the colony which have separated and acquired an ovoid outline. (c) A paraclone in which few flattened cells remain in contact and the colony consists largely of scattered ovoid cells. Differences in colony morphologies are readily distinguishable but the continuous gradient of change from one colony form to the next makes classification somewhat arbitrary.