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The induction of induced pluripotent stem (iPS) cells by Oct‐3/4, Sox2, c‐Myc and KLF4. Retroviral transfection of Oct‐3/4, Sox2, c‐Myc and KLF4 into mouse fibroblasts results in the induction of pluripotent iPS cells. The introduction of three factors devoid of Sox2 results in cells with embryonic stem‐like morphology, but they are nulipotent. Nanog is dispensable for induced pluripotent stem (iPS) cell induction.
