Figure 9.

The circ_0078767/miR‐330‐3p/RASSF1A axis suppressed tumour formation in vivo. A, Representative tumours induced by circ_0078767, si‐circ_0078767 or cotransfected with miR‐330‐3p inhibitor or RASSF1A. B, Inhibiting circ_0078767 expression upregulated tumour volume; however, co‐transfection of an miR‐330‐3p inhibitor or RASSF1A significantly reversed this effect. C, The increased tumour weights induced by si‐circ_0078767 were abrogated by co‐transfection with miR‐330‐3p inhibitor or RASSF1A. D, RASSF1A in tumours from the animal model was measured by Western blot. E, qRT‐PCR results showed that miR‐330‐3p expression in tumours was significantly higher than that in adjacent tissues. F, qRT‐PCR results showed that circ_0078767 expression in tumours was significantly higher than that in adjacent tissues. G‐H, Ki67 was selected as a tumour marker and was measured by immunohistochemistry (I) RASSF1A mRNA was extracted from groups of tumours and analysed by qRT‐PCR. The data are from one representative experiment among three that were performed identically and are expressed as the means ± SD. **P < 0.01