Warner 2016.

Methods	Setting: Olmsted County, MN, USA; hospital‐based Recruitment: Identified through electronic medical records. Study personnel then approached the potential participants to confirm eligibility
Participants	600 adult smokers, 51% M, av. age 46.3, av. cigs/day 14.4
Interventions	1. Brief (˜5‐min) cessation advice: Quote: "Consisted of the first four of the 5A’s (Ask, Advise, Assess, Assist, and Arrange), including advice and brief assistance in reviewing tips to help maintain abstinence using a brochure. The brochure included the study quitline number but did not specifically encourage its use." 2. Brief (˜5‐minute) quitline facilitation intervention: Quote: "A single brief quitline facilitation intervention (also ˜5 minutes in duration, slightly modified from that piloted in the authors’ prior studies of presurgical patients) was delivered. Based on principles of Social Cognitive Therapy, it included advice to quit and quitline information. Its purpose was to facilitate quitline utilization, not to provide assistance with quitting, but to overcome cognitive barriers to quitline utilization. A written brochure that included information about the quitline and a wallet‐sized “quit‐card” were provided. If patients were amenable, study personnel then contacted the quitline provider, preferably by direct phone call (“warm handoff”) to enroll the patient for quitline services and arrange for an initial counseling call. If this direct contact could not be made, faxed referrals were sent to the quitline provider. Based on early experiences that it was difficult for the quitline to re‐contact patients while in hospital, the goal was to complete the first counseling session immediately after the in‐hospital quitline intake. Subsequent counseling sessions were scheduled by quitline counselors." NRT was offered to all participants: free 2‐week supply of nicotine patches
Outcomes	Abstinence at 6 m (7‐day PP) Validation: Urine anabasine levels < 2 ng/mL
Notes	New for 2018 update Funding: "This work was supported by grant RC‐2012‐0001 from ClearWay Minnesota." Declarations of interest: none reported
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Quote: "using dynamic randomization allocation based on the Mayo Clinic Study Data Management System, a proprietary web application for data entry and management. Randomization was stratified based on nursing unit to ensure the number of subjects assigned to each of the two intervention groups remained balanced within that unit, enhancing the homogeneity of admitting diagnoses between groups"
Allocation concealment (selection bias)	Unclear risk	Not described
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Biochemically‐confirmed smoking cessation
Incomplete outcome data (attrition bias) All outcomes	Low risk	Low attrition ˜30% and comparable across arms