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. 2012 Jun 5;45(4):352–364. doi: 10.1111/j.1365-2184.2012.00825.x

Figure 8.

Figure 8

Western blot analysis outlining effects of original docetaxel and novel docetaxel analogue (CQMU‐0519) on Bcl‐2 family of apoptosis regulatory proteins. Densitometric analysis revealed upregulation of Bax, Bad, tBid (15 kDa) with lower expressions of Bcl‐2 and Bcl‐xL in A549 and SKVO3 cells (a–d) (*P < 0.05). However, there was no increase in target levels of these proteins in treated MCF7 cells (e–f). However, PARP (85 kDa) was cleaved in all three cell lines (a–f) (*P < 0.05). β‐actin was used as an internal loading control.