Figure 5.

Summary of our main findings and some hypotheses we have raised for potential mechanisms in OT, involving the microRNAs comprised in the OT-CR differential profile. At the top of the figure, we show the set of microRNAs comprised in the OT-CR differential profile indicating those presenting higher or lower levels in OT. Then, we indicate the microRNAs whose levels may be preserved in OT in relation the physiologic state, and those with decreased levels. Among the potential mechanisms of tolerance involving these microRNAs, we highlight the death receptor pathway. Our hypothesis is that OT may also involve mechanisms mediated by microRNAs affecting the cell death pathway. These mechanisms would favor the survival of cells most likely with the regulatory profile, as well as of graft tissue, contrary to what is could be occurring in CR. Understanding these mechanisms may contribute to the development of novel strategies to promote cell survival in renal transplantation, favoring the development of transplantation tolerance, in the future.