Table 1.
Demographic and clinical data of study subjects.
| Study Subjects | OT 03 | OT 08 | OT 10 | OT 16 | OT 62 | OT 75 | OT 90 | OT 91 | OT (n = 8) | CR (n = 12) | HI (n = 12) | p value OT x CR | p-value OT x HI |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Age (Years) | 55 | 42 | 42 | 48 | 32 | 37 | 31 | 57 | 43 (32–57) | 45 (28–59) | 45 (29–61) | p = 0.6742 | p = 0.6332 |
| Sex (F, M) | M | M | F | F | M | M | F | M | F = 3; M = 5 | F = 2; M = 10 | F = 6; M = 6 | p = 0.3471 | p = 0.6691 |
| Transplantation number | 1 | 2 | 2 | 1 | 1 | 2 | 1 | 1 | 1 (n = 5); 2 (n = 3) | 1 (n = 2); 2 (n = 10) | NA | p = 0.6682 | NA |
| Time of transplantation (years) | 27 | 5 | 12 | 28 | 17 | 6 | 11 | 31 | 17 (5–28) | 7 (1–13) | NA | p = 0.018*2 | NA |
| HLA (A, B, DR) mismatches | 3 | 4 | 0 | 0 | 3 | 1 | 1 | 6 | 6 (n = 1); 4 (n = 1); 3 (n = 2); 1 (n = 1); 0 (n = 2) | 6 (n = 4); 5 (n = 3); 3 (n = 4); 1 (n = 2); | NA | p = 0.012*2 | NA |
| Donor (Live/ Deceased) | Live | Deceased | Live | Live | Live | Deceased | Live | Live | Live (n = 6) Dead (n = 2) | Live (n = 4) Dead (n = 8) | NA | p = 0.1691 | NA |
| Creatinine | 1.15 | 1.62 | 0.89 | 0.74 | 1.71 | 1.1 | 1.4 | 1.3 | 1.23 (0.89–1.71) | 1.93 (1.3–4.4) | NA | p = 0.014*3 | NA |
| Immunosuppressive time free (years) | 7 | 2 | 2 | 8 | 4 | 4 | 2 | 30 | 7 (2–30) | NA | NA | NA | NA |
| Immunosuppressive used | Aza, Pred | Pred Tacro MMF | Cya Aza Pred | Pred Aza | Cya Aza Pred | Tacr Pred MMF Eve | TacrMPS Pred | Aza Pred | Pred (n = 8) Tacro (n = 3) MMF (n = 2) MPS (n = 1) Cya (n = 2) Aza (n = 5) Eve (n = 1) | Pred (n = 1) Tacro (n8) MMF (n = 3) MPS (n = 6) Cya (n = 1) Aza (= 1) Eve(n = 1) | NA | NA | NA |
The ordinal variables were initially analyzed by the Shapiro-Wilk test to verify normality.
Chi-square test;
t test;
Mann-Whitney.
The numerical data are represented as mean. The minimum and maximum values of the age of each group, transplant time, number of HLA disparities, donor type and creatinine are shown in parenthesis. The
p < 0.005. Operational Tolerance (OT) n = 8; Chronic Rejection (CR) n = 12; Healthy Individuals (HI) n = 12. NA, Not applicable; F, Female; M, Male; Pred, prednisone; Tacro, tacrolimus; MMF, mycophenolate mofetil; MPS, mycophenolate sodium, Cya, cyclosporine A; Aza, azathioprine, Eve, Everolimus. The data provided refer to the date of sample collection and inclusion in Multicenter study.