Table 1.
Levels of factors secreted from MSCs derived from CV, AF and BM at the beginning of the culture time. Results from the average of three samples are shown for each MSC. (−) value <50 pg/ml, (+) 50 pg/ml < value < 500 pg/ml, (++) 500 pg/ml<value<5000 pg/ml, (+++) value > 5000 pg/ml. There were no significant differences between the time points analysed
| 1 × 106 cells | CV MSCs HS | CV MSCs PL | CV MSCs FBS | AF MSCs HS | AF MSCs FBS | BM MSCs HS | BM MSCs PL | BM MSCs FBS |
|---|---|---|---|---|---|---|---|---|
| IL‐1β | − | − | − | − | − | − | − | − |
| IL‐1ra | + | + | + | − | − | + | + | + |
| IL‐2 | − | − | − | − | − | − | − | − |
| IL‐4 | − | − | − | − | − | − | − | − |
| IL‐5 | − | − | − | − | − | − | − | − |
| IL‐6 | ++ | +++ | ++ | ++ | ++ | ++ | ++ | ++ |
| IL‐7 | − | − | − | − | − | − | − | − |
| IL‐8 | +++ | ++ | +++ | +++ | +++ | +++ | ++ | +++ |
| IL‐9 | + | − | + | − | + | + | − | + |
| IL‐10 | − | − | − | + | + | + | + | + |
| IL‐12p70 | + | − | − | + | + | + | − | + |
| IL‐13 | − | − | − | − | − | − | − | − |
| IL‐15 | + | + | − | − | − | + | + | + |
| IL‐17 | + | − | + | + | + | + | − | + |
| Eotaxin | + | − | − | − | − | − | − | − |
| FGF‐β | + | − | + | + | + | + | − | + |
| G‐CSF | + | − | − | − | − | − | − | − |
| GM‐CSF | + | − | + | + | + | + | − | + |
| IFN‐γ | + | + | + | + | + | + | + | + |
| IP‐10 | ++ | + | ++ | + | + | + | − | + |
| MCP‐1 | ++ | +++ | ++ | ++ | ++ | ++ | ++ | ++ |
| MIP‐1α | + | − | + | + | + | + | − | + |
| MIP‐1 β | ++ | − | + | + | + | + | − | + |
| PDGFbb | − | − | − | − | − | − | − | − |
| RANTES | − | − | − | − | − | − | − | − |
| TNF‐α | + | − | + | + | + | + | + | + |
| VEGF | +++ | − | +++ | +++ | +++ | +++ | ++ | +++ |
AF, amniotic fluid; BM, bone marrow; CV, chorionic villi; HS, human allogeneic serum; MSCs, mesenchymal stem cells; PL, platelet lysate.