Table 2.
Genes upregulated in hMSC culture (fold change > 5)
| Gene Symbol | Description | Fold change‐P5 | Fold change‐P8 | |
|---|---|---|---|---|
| 1 | PRUNE2 | Prune homolog 2 (Drosophila) | 5.34 up | 12.05 up |
| 2 | EPGN | Epithelial mitogen homolog (mouse) | — | 12.47 up |
| 3 | C4orf3 | Chromosome 4 open reading frame 3 | 5.91 up | 12.50 up |
| 4 | SLC7A11 | Solute carrier family 7 | 5.16 up | 12.72 up |
| 5 | TUBA1B | Tubulin, alpha 1b | 49.14 up | 17.39 up |
| 6 | ACTC1 | Actin, alpha, cardiac muscle 1 | — | 18.17 up |
| 7 | CHORDC1 | Cysteine and histidine‐rich domain (CHORD)‐containing 1 | 17.76 up | 28.48 up |
| 8 | FAM36A | Family with sequence similarity 36, member A | — | 5.00 up |
| 9 | MAPRE3 | Microtubule‐associated protein, RP/EB family, member 3 | — | 5.00 up |
| 10 | UAP1 | UDP‐N‐acetylglucosamine pyrophosphorylase 1 | — | 5.01 up |
| 11 | PREPL | Prolyl endopeptidase‐like | — | 5.02 up |
| 12 | VGLL3 | Vestigial‐like 3 (Drosophila) | — | 5.05 up |
| 13 | PGRMC2 | Progesterone receptor membrane component 2 | — | 5.07 up |
| 14 | PLD5 | Phospholipase D family, member 5 | — | 5.08 up |
| 15 | AMIGO2 | Adhesion molecule with IgG‐like domain 2 | — | 5.10 up |
| 16 | ANKRD1 | Ankyrin repeat domain 1 (cardiac muscle) | — | 5.10 up |
| 17 | SC4MOL | Sterol‐C4‐methyl oxidase‐like | — | 5.10 up |
| 18 | SERPINB2 | Serpin peptidase inhibitor, clade B (ovalbumin), member | 9.07 up | 5.10 up |
| 19 | FAM198B | Family with sequence similarity 198, member B | — | 5.12 up |
| 20 | C4orf18 | Chromosome 4 open reading frame 18 | — | 5.16 up |
| 21 | BCAP29 | B‐cell receptor‐associated protein 29 | — | 5.18 up |
| 22 | HAPLN1 | Hyaluronan and proteoglycan link protein 1 | — | 5.18 up |
| 23 | LYPD6B | LY6/PLAUR domain containing 6B | — | 5.26 up |
| 24 | MANBA | Mannosidase, beta A, lysosomal | — | 5.27 up |
| 25 | LMBR1 | Limb region 1 homolog (mouse) | — | 5.33 up |
| 26 | COL8A1 | Collagen, type VIII, alpha 1 | — | 5.34 up |
| 27 | ATP11B | ATPase, class VI, type 11B | — | 5.35 up |
| 28 | FMN2 | Formin 2 | — | 5.39 up |
| 29 | PLOD2 | Procollagen‐lysine, 2‐oxoglutarate 5‐dioxygenase 2 | — | 5.42 up |
| 30 | NEK7 | NIMA (never in mitosis gene a)‐related kinase 7 | — | 5.45 up |
| 31 | TOMM20 | Translocase of outer mitochondrial membrane 20 homolog | — | 5.50 up |
| 32 | SEPT7 | Septin 7 | — | 5.53 up |
| 33 | IVNS1ABP | Influenza virus NS1A binding protein | — | 5.56 up |
| 34 | ITGA6 | Integrin, alpha 6 | 5.05 up | 5.58 up |
| 35 | ELTD1 | Latrophilin and seven transmembrane domain containing | 6.08 up | 5.63 up |
| 36 | HINT3 | Histidine triad nucleotide binding protein 3 | — | 5.64 up |
| 37 | OGFRL1 | Opioid growth factor receptor‐like 1 | — | 5.64 up |
| 38 | SERPINI1 | Serpin peptidase inhibitor, clade I (neuroserpin) | — | 5.64 up |
| 39 | TOR1AIP2 | Torsin A interacting protein 2 | — | 5.66 up |
| 40 | PDE11A | Phosphodiesterase 11A | — | 5.69 up |
| 41 | RAP1B | RAP1B, member of RAS oncogene family | 5.23 up | 5.71 up |
| 42 | FAM174A | Family with sequence similarity 174, member A | — | 5.73 up |
| 43 | XRCC4 | X‐ray repair complementing defective repair in Chinese ham | — | 5.73 up |
| 44 | SYT14 | Synaptotagmin XIV | — | 5.78 up |
| 45 | EVI5 | Ecotropic viral integration site 5 | — | 5.81 up |
| 46 | STC1 | Stanniocalcin 1 | — | 5.87 up |
| 47 | ME1 | Malic enzyme 1, NADP(+)‐dependent, cytosolic | — | 6.08 up |
| 48 | DLG1 | Discs, large homolog 1 (Drosophila) | 6.23 up | 6.11 up |
| 49 | SLITRK1 | SLIT and NTRK‐like family, member 1 | — | 6.13 up |
| 50 | FAM38B | Family with sequence similarity 38, member B | — | 6.32 up |
| 51 | MCART1 | Mitochondrial carrier triple repeat 1 | — | 6.32 up |
| 52 | PCDH10 | Protocadherin 10 | — | 6.44 up |
| 53 | PLCB4 | Phospholipase C, beta 4 | — | 6.46 up |
| 54 | FLRT2 | Fibronectin leucine‐rich transmembrane protein 2 | — | 6.62 up |
| 55 | SCN9A | Sodium channel, voltage‐gated, type IX, alpha subunit | — | 6.66 up |
| 56 | ERV3 | Endogenous retroviral sequence 3 | — | 6.74 up |
| 57 | SCIN | Scinderin | — | 6.99 up |
| 58 | CD36 | CD36 molecule (thrombospondin receptor) | — | 7.07 up |
| 59 | FGF7 | Fibroblast growth factor 7 (keratinocyte growth factor) | — | 7.17 up |
| 60 | CPE | Carboxypeptidase E | — | 7.19 up |
| 61 | VANGL1 | Vang‐like 1 (van Gogh, Drosophila) | 7.50 up | 7.20 up |
| 62 | PVRL3 | Poliovirus receptor‐related 3 | — | 7.27 up |
| 63 | EPHA5 | EPH receptor A5 | — | 7.39 up |
| 64 | HIST1H2BK | Histone cluster 1, H2bk | 5.60 up | 7.72 up |
| 65 | MAMDC2 | MAM domain containing 2 | — | 7.78 up |
| 66 | ATRNL1 | Attractin‐like 1 | — | 7.89 up |
| 67 | COL11A1 | Collagen, type XI, alpha 1 | — | 7.90 up |
| 68 | ARHGAP29 | Rho GTPase activating protein 29 | 9.08 up | 8.62 up |
| 69 | DPP4 | Dipeptidyl‐peptidase 4 | 5.14 up | 9.62 up |
| 70 | ANKRD36B | Ankyrin repeat domain 36B | 7.58 | — |
| 71 | CCDC99 | Coiled‐coil domain containing 99 | 5.03 up | — |
| 72 | USP53 | Ubiquitin‐specific peptidase 53 | 5.19 up | — |
The fold change is related to passage 1.
(—) Not differentially expressed.