Table 2.
Functional characterization of deregulated miRNAs in rhabdomyosarcoma (RMS)
| Name | Up‐ or down‐regulation (Rhabdomyosarcoma/Normal) | Target gene | Role | Reference |
|---|---|---|---|---|
| miR‐29 | Down | YY1, PAX3, CCND2 | Tumour suppressor | 3, 44 |
| miR‐301 | Up | oncogene | 7 | |
| miR‐27a | Down | Tumour suppressor | 7 | |
| miR‐26a | Down | Tumour suppressor | 7 | |
| miR‐1 | Down | c‐Met, PAX3, CCND2 | Tumour suppressor | 37, 38, 39, 40, 44 |
| miR‐206 | Down | c‐Met, PAX3, CCND2 | Tumour suppressor | 37, 38, 39, 44 |
| miR‐133a | Down | TPM4 | Tumour suppressor | 39, 40 |
| miR‐133b | Down | Tumour suppressor | 39 | |
| miR‐183 | Up |
EGR1 PTEN |
oncogene | 41 |
| miR‐17, miR‐19a, miR‐19b, miR‐20a, miR‐92a | Up | 42 | ||
| miR‐203 | Down | p63 | Tumour suppressor | 43 |
| miR‐378a‐3p | Down | IGF1R | Tumour suppressor | 36 |
| miR‐485‐3p | Up | NF‐YB | oncogene | 45 |
| miR‐450b‐5p | Down |
ENOX2 PAX9 |
Tumour suppressor | 47 |
| miR‐214 | Down | N‐ras | Tumour suppressor | 49 |