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. 2001 Dec 24;33(5):261–274. doi: 10.1046/j.1365-2184.2000.00191.x

Figure 3.

Figure 3

Regulation of the G2/M transition. DNA damage inhibits G2/M progression via two mechanisms. Upon DNA damage the p53 protein is stabilized and activated as a transcription factor. One of its targets is the 14‐3‐3 σ gene, which mediates the sequestration of cdc2/cycB in the cytoplasm. DNA damage also induces the activation of the Chk1/Chk2 protein kinases through an ATM‐dependent mechanism. Chk1/Chk2‐dependent phosphorylation of Cdc25C induces its binding to 14‐3‐3 proteins which inactivate it by sequestering it in the cytoplasm.