Figure 3.

Effect of Onc (b), RA (c), n‐butyrate (d), Onc + RA (e) and Onc plus n‐butyrate (f) on cell cycle and apoptosis of HL‐60 cells: bivariate analysis of cellular DNA content and DNA strand breaks ( Gorczyca et al. 1992 ). Apoptotic cells (Ap) are identified by the presence of DNA strand breaks. Their increased frequency in the cultures treated with Onc + RA (e) and Onc plus n‐ butyrate (f) for 72 h is apparent. (a) cells from the untreated, control culture. Insets show the DNA content frequency histograms of these cells.