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. 2012 Apr 2;45(3):199–206. doi: 10.1111/j.1365-2184.2012.00819.x

Figure 5.

Figure 5

Effect of BAY 73‐6691 PDE 9 inhibitor, in inhibition of cell proliferation of the breast cancer cell lines. Cells were treated with different concentrations of BAY 73‐6691 for 24, 48 and 72 h, and proliferation was measured by MTT assay. BAY 73‐6691 reduced cell proliferation in MCF‐7(5A) and MDA‐MB‐468(5B) breast cells in a time‐ and dose‐dependent manner. Each value is presented as mean ± SD of three experiments (Each triplicate). *P < 0.05, **P < 0.01 are significant compared to untreated control groups.