Table 2.

Mutivariate analysis by Cox proportional hazards

Variable	Category	Hazard ratio	95% CI	P‐value
Age (year)	<57	1	1.08–7.24	0.03
	≥57	2.80
Gender	Female	1	0.49–2.06	0.99
	Male	1.00
Histological types	Papillary	1	1.52–6.44	0.002
	Non‐papillary	3.13
Metastasis	No	1	1.23–6.29	0.014
	Presence	2.78
HO‐1 staining	Low	1	1.16–5.08	0.019
	High	2.42
Adjuvant chemotherapy	No	1
	5‐FU‐based	0.49	0.17–1.38	0.176
	Oral fluoropyrimidine	1.73	0.82–3.65	0.149