Figure 6.

Influence of IVM on the level of apoptosis‐associated proteins in HeLa cells. IVM induced the release of cytochrome c into the cytosol in a dose‐dependent manner (A). Cyto denotes cytosolic fractions. Bax expression increased and Bcl‐2 expression decreased as the IVM concentrations increased (C). The densitometric analysis results of Cyto cytc and Bax/Bcl‐2 were shown in the right panel (B and D). β‐actin was used as an equal loading control. The data are shown as the means ± SD of three independent experiments. **P < 0.01. IVM, ivermectin