Figure 3.

  Bi‐orientation and kinetochore attachment errors. (a) In amphitelic attachment, sister kinetochores are correctly attached to microtubules emanating from opposite poles of the spindle, leading to chromosome bi‐orientation. (b) In monotelic attachment, the chromosome is mono‐oriented as one kinetochore is attached to the microtubules from one spindle pole, while its sister is unattached. (c) In syntelic attachment, the chromosome is mono‐oriented but, in this case, both sister kinetochores are attached to microtubules from the same spindle pole. (d) In merotelic attachment, one sister kinetochore is attached to microtubules from both spindle poles, the chromosome is improperly bi‐oriented and, if left uncorrected, can produce an anaphase lagging chromosome.