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Natural compounds utilized in prostate cancer. Magnolol inhibits prostate cancer cells by induction of apoptosis through inhibiting Akt enzyme and p‐EGFR, p‐PI3K and p‐Akt activity, reducing Ser phosphorylation in pro‐apoptotic protein Bad. Mahanine inhibits cell population growth by inducing apoptosis of both androgen‐responsive LNCaP and androgen‐independent PC‐3 cells by inhibiting phosphorylation of PDK1, which results in deactivation of Akt and down‐regulation of Bcl‐XL.
