Table 3.
Autophagy‐related drugs or chemical compounds in NSCLC
| Drugs or chemical compounds | Autophagic pathways | Cell lines and primary cells | Autophagy role | References |
|---|---|---|---|---|
| Ouabain | JNK‐dependent decrease of Bcl‐2 | A549 and H1975 cell lines | Pro‐death | 81 |
| Digoxin | Activation of AMPK and ERK1/2 | A549 and H460 cell lines | Pro‐death | 80 |
| Harmol | Activation of ERK1/2 | A549 cell line | Pro‐death | 82 |
| PM02734 | Inhibition of the Akt/mTOR pathway, and activation of DAPK | H322 and A549 cell lines | Pro‐death | 83 |
| OB | Down‐regulation of Nrf2 | A549 cell line | Pro‐death | 84 |
| SU11274 | p53 activation | A549 cell line | Pro‐death | 85 |
| TW01001 | – | A549 cell line | Pro‐death | 86 |
| Erlotinib | p53 nuclear translocation, AMPK activation and mTOR suppression | HCC827 and HCC4006 cell lines | Pro‐survival | 87 |
| β‐Elemene | PI3K/Akt/mTOR/p70S6K1 inhibition | A549 cell line | Pro‐survival | 90 |
| Salinomycin | Akt1‐mTOR inhibition | A549 cell line | Pro‐survival | 91 |
| Sodium selenite | ROS | A549 cell line | Pro‐survival | 92 |
| NVP‐BEZ235 | PI3K/mTOR inhibition | NSCLC cell lines A549, H522, H460 and H1792, etc. | Pro‐survival | 93 |
| AT101 | – | A549 cell line | Pro‐survival | 94 |
| 5‐FU | – | A549 cell line | Pro‐survival | 95 |
| MEMC | – | NCI‐H460 cell line | Pro‐survival | 96 |
| Plumbagin | Inhibition of PI3K/Akt/mTOR | A549 and H23 cells | – | 97 |
| Calyxin Y | JNK activation and overexpression of Atg proteins | NCI‐H460 cell line | – | 98 |
| OP‐B | Inhibition of PI3K/Akt | NSCLC cell lines H460, NCI‐H460 and NCI‐H157 etc. | – | 99 |