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. 2009 Sep 24;42(6):823–837. doi: 10.1111/j.1365-2184.2009.00641.x

Figure 1.

Figure 1

 Schematic structure of the combined pharmacokinetic–pharmacodynamic (PK‐PD) model of murine granulopoiesis. The model is based on concatenated cell compartments. S represents early stem cells; CG, CFU‐G; PGB, proliferating granulocytic precursors; MGB, maturing granulocytic precursors; and GRA, circulating granulocytes (ANC). The identified PK model is attached to the PD model. Toxicity is modelled by an instantaneous cell depletion. The model is explained in detail in the literature (30).