Table 2.
Length of neutropenic episode defined as days with absolute neutrophil count (ANC) below normal. Number of animals with specified number of neutropenic days is presented for all dosing and timing schedules
| G‐CSF schedule | Pegfilgrastim | Maxy‐G34 | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Days with neutropenia | Same day | Next day | Same day | Next day | |||||
| 100 μg/kg (N = 6) | 300 μg/kg (N = 6) | 1000 μg/kg (N = 6) | 100 μg/kg (N = 6) | 30 μg/kg (N = 6) | 100 μg/kg (N = 6) | 300 μg/kg (N = 6) | 30 μg/kg (N = 7) | 100 μg/kg (N = 7) | |
| 1 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 1 |
| 2 | 0 | 4 | 6 | 1 | 0 | 2 | 2 | 1 | 3 |
| 3 | 2 | 2 | 0 | 2 | 2 | 4 | 2 | 5 | 3 |
| 4 | 2 | 0 | 0 | 2 | 4 | 0 | 0 | 1 | 0 |
| 5 | 2 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
G‐CSF, granulocyte colony‐stimulating factor.