Table 3.

 Quantities of the pharmacokinetic (PK) model for both pegfilgrastim and Maxy‐G34. We present type, unit and explanation of all quantities. Furthermore, PK parameter estimates are presented for both pegfilgrastim and Maxy‐G34 based on fitting the PK model to the data imprinting measured absolute neutrophil count (ANC) levels. Estimates were compared between the drugs. Parameter estimates were considered comparable if the model fit did not change by more than 10% by exchanging the estimates

Symbol	Type	Unit	Explanation	Fitted value for pegfilgrastim	Fitted value for Maxy‐G34	Relation between parameter estimates
,	Function of time to be calculated	ng	Contains of the sub‐compartments of the subcutaneous tissue	–	–	–
	Function of time to be calculated	ng/ml	Contain of the central compartment (serum concentration)	–	–	–
	Function of time to be calculated	ng/ml	Contain of the peripheral compartment	–	–	–
Dose	Given function of time	ng/h	Applied dose per hour	–	–	–
	Parameter	ng/h	Elimination in subcutaneous tissue	35	150	Greater for Maxy‐G34
	Parameter	ng	Michaelis‐Menten constant of subcutaneous elimination	190	1900	Greater for Maxy‐G34
k sc	Parameter	1/h	Transition constant from subcutaneous tissue to central compartment causing a time delay (lag)	0.07	0.06	Comparable
vol	Parameter	ml	Volume of distribution	15.0	17.0	Comparable
k 12	Parameter	1/h	Transition from central to peripheral compartment	0.0003	0.0004	Negligible for both derivatives
k 21	Parameter	1/h	Transition from peripheral to central compartment	0.13	0.12	Comparable
	Parameter	1/h	Unspecific (renal) elimination	0.07	0.02	Greater for pegfilgrastim
	Parameter	ng/(ml*h)	Specific elimination via G‐CSF receptors or neutrophil elastase	0.04	0.02	Greater for pegfilgrastim
	Parameter	ng/ml	Michaelis‐Menten constant of specific elimination	0.1	0.5	Greater for Maxy‐G34
ANC	Given function of time	–	Circulating ANC in 109/l	–	–	–
α	Parameter	–	Exponent of ANC	0.6	0.5	Comparable

G‐CSF, granulocyte colony‐stimulating factor.