Table 4.
Model predictions and interpolation of toxicity of different dosing and timing schedules of pegfilgrastim and Maxy‐G34 after cyclophosphamide administration (CP). We simulated three different timing schedules and four doses in a full‐factorial design. Area over the curve (AOC) is the area between the baseline and the simulated time course of ANC in the nadir. DN and minimal ANC were calculated to evaluate toxicity. Both, high AOC, high DN and low minimal cell count indicate high toxicity as well
| Timing/dosing (μg/kg) | Pegfilgrastim | Maxy‐G34 | ||||
|---|---|---|---|---|---|---|
| DN (h) | Minimal ANC (109/l) | AOC (109h/l) | DN (h) | Minimal ANC (109/l) | AOC (109h/l) | |
| Same day | ||||||
| 30 | 76 | 0.061 | 23.0 | 62 | 0.088 | 17.8 |
| 100 | 49 | 0.13 | 12.4 | 45 | 0.17 | 10.0 |
| 300 | 45 | 0.17 | 10.3 | 32 | 0.26 | 5.2 |
| 1000 | 35 | 0.24 | 6.0 | 26 | 0.31 | 3.3 |
| Next day | ||||||
| 30 | 73 | 0.23 | 14.6 | 50 | 0.14 | 12.4 |
| 100 | 43 | 0.17 | 9.9 | 39 | 0.21 | 7.7 |
| 300 | 38 | 0.22 | 7.4 | 29 | 0.28 | 4.4 |
| 1000 | 30 | 0.29 | 4.3 | 24 | 0.33 | 2.8 |
| Two days after CP | ||||||
| 30 | 34 | 0.24 | 6.0 | 40 | 0.19 | 8.1 |
| 100 | 36 | 0.21 | 7.1 | 35 | 0.22 | 6.5 |
| 300 | 33 | 0.23 | 6.0 | 30 | 0.26 | 4.7 |
| 1000 | 29 | 0.28 | 4.3 | 26 | 0.30 | 3.4 |