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. Author manuscript; available in PMC: 2019 May 2.
Published in final edited form as: Mol Cancer Res. 2018 Apr 18;16(8):1263–1274. doi: 10.1158/1541-7786.MCR-17-0730

Figure 4. “Meta-Galaxy” analysis restricted to the 16 T-cell ALL samples identified protein patterns associated with the Hispanic ethnicity.

Figure 4.

(A) Block clustering limited to the T-cell ALL samples enabled recognition of 6 protein constellations (horizontally) and 3 protein signatures (vertically). The annotation bar shows patient characteristics for ethnicity and suggests ethnicity-associated constellations. (B) Proteins with significantly higher or significantly lower protein expression levels relative to normal CD34+ cells within T-ALL constellation 3 (enriched for Hispanic ethnicity) and constellation 5 (enriched for non-Hispanic ethnicity) are shown. Proteins in constellation 3 were predominantly involved in PFG “Cell Cycle”, “FLI1” and “IAP-Apoptosis” and proteins in constellation 5 were involved PFG “BH3 Apoptosis”, “Cell Cycle”, “FLI1”, “IAP-Apoptosis” and “MEK”. Colors reflect the relative median expression within that specific constellation, ranged from the lowest (dark blue) to relatively normal (cyan-green-yellow) to the highest (maroon) expression.